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–100

–50

0

50

100

Ansell et al; ASH 2015

Percent Change From Baseline

in Target Lesions/Tumor Burden

0 6 12 18 24 30 36 42 48 54 60 66 72 78 84 90 96 102 108 114

On treatment, ongoing response

Off treatment without progression

Progressive disease, following response

or stable disease

First occurrence of new lesion

Nivolumab in r&r HL

Durability of response