701 / 1631
Ardeshna KM,
et al. Lancet
2003; 362:516–522.
No survival benefit with immediate chemotherapy
treatment vs watch and wait in patients with
asymptomatic FL
Time (years)
0 4 8 12 16 20 24
Advanced stage but clinically
non-aggressive (BNLI) defined by absence of:
Pruritis or B symptoms
Rapid progression in last 3 months
Life-threatening organ involvement
Cytopenias secondary to
bone marrow involvement
Bone lesions
Renal infiltration
Macroscopic liver involvement
Cumulative survival
(%)
0
20
40
60
80
100
Observation (n = 151)
Chlorambucil (n = 158)
Overall survival