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Dose response relationship for cardiovascular event and mean

heart radiation dose (from EORTC randomized trials in HL)

Maraldo MV et al. Lancet Haematol 2015; 2: e492-502

Suggested constraints:

≤ 4 Gy: should be obtained in all

but the most challenging cases

5-15 Gy: acceptable

> 15 Gy: consider omission or

modification of plan