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Interactions between the tumour microenvironment and
malignant B cells play an important role in B-cell homing,
adhesion and migration through activation of intracellular
pathways in the B cells.
1,2
BTK’s pivotal role in signalling through B-cell surface
receptors results in activation of pathways necessary for B-
cell trafficking, chemotaxis and adhesion.
3
Through irreversible inhibition of BTK, ibrutinib is believed
to disrupt key malignant processes and:
3,4
•
Induce apoptosis
•
Inhibit adhesion (may lead to lymphocytosis)
•
Inhibit migration and homing (prevents malignant cells from
homing back to lymph organs)
Ibrutininb
Mechanism of action
1.
de Gorter DJJ, et al. Immunity 2007;26:93-104.
2.
Burger JA, et al. Blood 2009;114:3367-3375.
3.
Buggy J
et al. Int Rev Immunol 2012; 31:119-132.
4.
Chavez J, et al. Core Evid 2013; 8:37-45.
Chemical structure of ibrutinib
4