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Improvement in EFS, PFS and OS
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Outcome of R-CHOP x 8 arm inferior to those observed in MInT with
R-CHOP x 6
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Excess utilisation of healthcare resource
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Excess of toxicity
Recher C
, et al Lancet
2011: 378:1858-1867.
R-ACVBP
R-CHOP
Toxicity (grade >3)
Neutropenia
78%
64%
Thrombocytopenia
30%
3%
Febrile neutropenia
38%
9%
Toxic deaths (n)
3
2