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Dose Density: UK R-CHOP14 vs. 21
Cunningham, D,
et al. Lance
t 2013; 381:1817–1826.
Newly
diagnosed
CD20+ve
DLBCL
R-CHOP21
CHOP21
8 cycles
Rituximab
8 cycles
R-CHOP14
CHOP14
6 cycles
Rituximab
8 cycles
Lenograstim Day 4-12
n=540
n=540
Stratified by
• IPI (0-1, 2, 3, 4-5)
• Age ≤60 vs. >60
• Treatment centre
1080 patients; 119 sites
Recruitment March 2005 - Nov 2008
R