901 / 1631
Thieblemont et al. JCO 2017
PFS
OS
36% patients
discontinued
therapy as a result
of toxicity (vs 16%
placebo)
72% required a
dose reduction
55% aged <70..? Fit
for an alternative
approach
PET positive at end
of induction had
greatest benefit
(HR=0.59 vs 0.78)