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What about the GCB Phenotype?...anything yet in the front line?
McCabe M T et al
. Proc Nat Acad Sci USA
2012;109:2989-2994
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Enhancer of Zeste 2 (EZH2) is the enzyme
component of the Polycomb Repressive
Complex 2 (PRC2) that methylates histone
H3 on lysine 27 (H3K27)
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Somatic activating mutations in EZH2 have
been identified in follicular and GCB-DLBCL
[Morin, 2010; Morin, 2011; Pasqualucci,
2011];
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The frequency of the most prevalent
mutation, Y641, 22% in DLBCL.
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Inhibitors in early phase investigation