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Conclusion
Dose to the anterior mandible could be constrained in
most patients. Planned use of this technique will further
inform pre-treatment dental assessments and allow
greater prospective planning of dental rehabilitation to
improve head and neck cancer survivorship.
EP-1033 Survival patterns in elderly head & neck
squamous cell carcinoma patients treated with
definitive RT
L. Sommers
1
, R. Steenbakkers
1
, H. Bijl
1
, J. Vemer-van
den Hoek
1
, J. Roodenburg
2
, S. Oosting
3
, S. De Rooij
4
, J.
Langendijk
1
1
UMCG University Medical Center Groningen, Radiation
Oncology, Groningen, The Netherlands
2
UMCG University Medical Center Groningen, Oral and
Maxillofacial Surgery, Groningen, The Netherlands
3
UMCG University Medical Center Groningen, Medical
Oncology, Groningen, The Netherlands
4
UMCG University Medical Center Groningen, University
Center for Geriatric Medicine, Groningen, The
Netherlands
Purpose or Objective
To investigate the effect of age on overall survival (OS),
cancer-specific survival (CSS) and non-cancer related
death (NCRD) in elderly (i.e. ≥70 years) head and neck
squamous cell carcinoma (HNSSC) patients treated with
definitive radiotherapy compared to younger patients and
determine the most important prognostic factors on these
survival endpoints.
Material and Methods
This was a retrospective analysis of prospectively collated
data of all consecutive HNSCC patients treated between
April 2007 and December 2014 at our department with
primary curative radiotherapy (66-70 Gy). Multivariable
association models for age were performed as well as a
multivariate analysis to identify potential prognostic
factors for these endpoints in only the elderly patients.
Results
The study population was composed of 674 consecutive
patients, including 168 elderly patients (24.9%). Three-
year OS and NCRD rates in elderly patients were
significantly worse, respectively p=0.007 and p<0.001. In
the multivariable association analysis on the relation
between age and OS, lymph node involvement and worse
WHO performance status were found significant
confounders. Multivariable association analysis between
age and NCRD only identified UICC stage as a significant
confounder. Worse WHO performance status, lymph node
involvement and specific tumor site were independent
prognostic factors for OS and CSS in the elderly patients.
Almost half of the elderly patients died during follow-up,
of which 45.0% due to index tumor. In elderly patients,
treatment with combined modality (radiotherapy with
systemic agent) was significantly associated with adverse
NCRD.