579 / 1082
S563
ESTRO 36 2017
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received 70 Gy /35 fractions /7 weeks
as per institutional protocol.
Results
Out of 54 patients only 46 patients (85%) completed NACT.
The most common side effect encountered during
induction chemotherapy is nausea and vomiting
representing 24%, followed by anorexia
representing 20%. After completion of induction
chemotherapy we had observed radiologically 24%, 63%
and 13% as complete, partial and non-responders
respectively. Acute toxicities like skin
reactions,mucosal reactions, xerostomia, pharyngitis/
hoarseness, upper GI side effects, and hematological
complications are more in Arm A than Arm B. Patients in
arm B has tolerated the local radiation
therapy compared to the patients in arm A. The quality
of life of patients in arm B compared to arm A was
appreciable during the local treatment. At 6
th
month
follow up local control, disease free
survival, overall survival, found in arm Avs arm B was 45%
vs 50%, 25% vs 35%, 85% vs 95% respectively. Progressive
disease and lost to follow up was 15% vs 10%, 10% vs 5%
respectively.
Patients died in arm A vs arm B was 5% vs 0% respectively.
Late radiation toxicities were assessed clinically at 6
months as per RTOG criteria and results had found not
statistically significant.
Conclusion
As observed in our study, 40 patients out of 54 has been
down staged. Symptoms like swallowing, anorexia, tumor
related pain, weight loss has been improved after
induction
chemotherapy.
However,
this
study definitely showed down staging and better
treatment tolerance towards IMRT arm in locally advanced
oropharyngeal carcinoma. A long term study for longer
follow up required for any statistically significant result.
Better response can be expected in early stage disease
EP-1028 MRI during radiotherapy: tumor geometry and
changes in organs at risk for head-and-neck patients
C. Grundmann
1
, K.A. Kessel
1,2
, S. Pigorsch
1
, S. Graf
3
, F.
Nüsslin
1
, S.E. Combs
1,2
1
Technische Universität München TUM, Department of
Radiation Oncology, München, Germany
2
Helmholtz Zentrum München, Institute for Innovative
Radiotherapy iRT, Neuherberg, Germany
3
Technische Universität München TUM, Department of
Otorhinolaryngology, München, Germany
Purpose or Objective
The use of image-guided radiotherapy (IGRT) leads to a
protection of OARs and a resulting reduction of side
effects for the patient. The aim of this work is to make a
statement about the relevance of MRI during radiotherapy
(RT) and illustrate the importance for radiation oncology.
Material and Methods
In a retrospective analysis, for 17 patients with head-and-
neck-cancer, the volume of eight OARs relevant for
swallowing was examined on MRI. Contouring was
performed on MRI before, during and after radiation and
the dose applied to the OARs was determined. Five of the
17 patients additionally participated in a voice and
swallowing test on average 22.2 months after RT. Three
questionnaires (Anderson Dysphagia Inventory (ADI-D),
Voice Handicap Index, EORTC QLQ-H&N35) were used to
evaluate subjective voice and swallowing disorders and
the
related quality of
life.
Additionally, fiberoptic endoscopic evaluation of
swallowing (FEES) and a voice test were performed,
including the assessment of the patient’s phonation and
the severity of the vocal disorder after the Dysphonia