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S596
ESTRO 36 2017
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4
Cristal Cnrs, Umr 9181, Villeneuve D'ascq, France
5
Cristal Cnrs, UMR 9181, Villeneuve d'Ascq, France
Purpose or Objective
The aim of this study was to evaluate the outcomes of
hypofractionated
robotic
stereotactic
radiotherapy for paraganglioma (PGL) of the head and
neck region
Material and Methods
We retrospectively studied 10 patients with benign head
and neck PGL(s), treated with robotic hRST using
Cyberknife at Oscar Lambert center between December
2008 and November 2012. Three of these patients were
diagnosed with recurrent tumors after surgery. The
median time to recurrence after surgery was 42 months.
None of them was embolised before radiotherapy. The
median follow-up was 49,2 months (range: 3-80,4
months).
Results
Eight patients presented with jugular-bulb PGL, 1 patient
with jugular-carotid body PGL and 1 patient with cerebral
posterior fossa PGL. The female/male ratio was 4/1. The
median tumor volume was 12,91 cm3 (range: 0,89-
141,51). The median dose was 36 Gy (range: 21-40). The
median number of fractions was 9 (range: 3-10).The tumor
growth and clinical outcome were evaluated every 6
months in the 2 years and then annually. The 1 and 3 year
freedom from disease progression was 100% and 88%
respectively. PGLs were stable in 8 patients, and partial
response was observed in 2 patients. No toxicity was
observed.
Conclusion
According to our early experience, robotic stereotactic
radiotherapy with Cyberknife seems to be successful
treatment option in management of head and neck PGL
EP-1094 Transoral Laser Microsurgery associated to
Radiotherapy in advanced laryngeal carcinomas.
I. Nieto Regueira
1
, V. Ochagavia
2
, A. Nuñez
2
, C. Ponte
2
, V.
Muñoz
2
1
Hospital do Meixoeiro. Complejo Hospitalario
Universitario de Vigo, Radiation Oncology, Vigo, Spain
2
Hospital do Meixoeiro. CHUVI, Radiation Oncology, Vigo,
Spain
Purpose or Objective
Transoral Laser Microsurgery is a surgical option treatment
that seems to have similar results to radiotherapy with or
without chemotherapy and offers similar outcomes in local
control and survival compared with open surgery,
preserving the larynx and its function.
Material and Methods
We analized the incidence of local side -effects during
adyuvant radiotherapy treatment in 24 locally advanced
laryngeal cancer patients who underwent laser
microsurgery.
In terms of TNM classification 14 patients were T3 stage
and
10
patients T4a
stage.
In 20 patients chemotherapy was associated to radiation
(83%)
The incidence of acute local side -effects during
Radiotherapy treatment were analized according to the
following factors: Laryngeal mucositis grade (RTOG scale);
Swallowing dysfunction meassured by Visual Analogue Pain
Scale; Radiation treatment duration and early
discontinuation of Radiation treatment.
All patients were treated with IMRT technique
Results
We observed an increased acute toxicity in this group of
patients compared to those who underwent
chemoradiation alone or associated to larynguectomy.
Ten patients presented grade 3 or 4 mucositis during the
treatment (41%)
The grade of swallowing dysfunction were up to 5 in all
patients and up to 8 in 6 (20%) meassured in a 1 to 10 pain
scale.
The median treatment duration were 45 days, that reveals
an increase compared to conventional cohort (48%)
Five patients required definitive early suspensión of
treatment (20%).
Eight patients underwent percutaneous gastrostomy when
the weight-loss was above 15%.
Three patients underwent tracheotomy due to severe
glottic stenosis produced by edema (12%).
Conclusion
In our experience Transoral Laser Microsurgery with
adyuvant Radiotherapy in advanced laryngeal cancer
patients has increased side-effects.
We do not recommend this association
EP-1095 Combined induction chemotherapy and
radiotherapy in locally advanced nasopharyngeal
carcinoma.
A. Gevorkov
1
, A. Boyko
1
, L. Bolotina
2
, A. Kornietskaya
2
,
T. Deshkina
2
1
Moscow Research Gerzen Oncology Institut, Radiation
oncology, Moscow, Russian Federation
2
Moscow Research Gerzen Oncology Institut,
Chemotherapy, Moscow, Russian Federation
Purpose or Objective
This prospective trial was conducted to evaluate the
efficacy and toxicity in previously untreated patients with
stage III-IV nasopharyngeal carcinoma who received an
induction chemotherapy followed by radiotherapy.
Material and Methods
From January 2004 to December 2010, 50 patients with
T2-4N2-3M0 squamous cell carcinoma of the nasopharynx
were treated with three or six cycles of docetaxel 75
mg/m2 (1-st day), cisplatin 75 mg/m2 (1-st day),
doxorubicin 45 mg/m2 (1-st day) (50 patients) followed by
radiotherapy using the conventional time/dose schedule.
Results
The response rate to chemotherapy was 88% (48%
complete response [CR]; 40% partial response [PR]), and
the overall CR rate after radiotherapy was 92%. With a
median follow-up period of 90 months, the 3-year survival
rate was 63,6% and 3-year loco-regional control was 45,8%.
The 5-year survival rate was 58% and 5-year loco-regional
control was 42%. Treatment was tolerated, but with
significant acute or chronic toxic effects and radiotherapy
treatment gaps.
Conclusion
The results of this study demonstrate that docetaxel,
cisplatin and doxorubicin followed by radiotherapy can
induce a durable remission in a high proportion of patients
with poor-prognosis stage III-IV nasopharyngeal
carcinoma. Treatment may be associated with severe
toxicity
and
unplanned
irradiation
delays.
EP-1096 Using DIR to study patterns of loco-regional
failure in patients with head and neck cancer
Y. Zheng
1
, D.J. Noble
2
, R. Jena
2
, N. Burnet
2
1
Addenbrooke's Hospital- Cambridge University Hospitals
NHS Foundation Trust, School of Clinical Medicine,
Cambridge,
United Kingdom
2
Addenbrooke's Hospital- Cambridge University Hospitals
NHS Foundation Trust, Department of Oncology- Cancer
Research UK VoxTox Research Group, Cambridge, United
Kingdom
Purpose or Objective
Using deformable image registration (DIR), we examined
patterns of loco-regional failure in patients who had
undergone IMRT with daily image guidance for head and
neck squamous cell carcinoma (HNSCC).
Material and Methods