1326-1327 / 2351
Author
N° pt
Stage
Survivals
Local control
Steiner
2001
129
Stage III+IV
Stage III+IV (5 yy)
OS: 47%
RFS: 69%
-
Vilaseca
2004
28
Stage II+IV
Stage II+IV (4 yy)
OS: 43%
LC T3 56.2% (n=49)
LC T4 100% (n=1)
organ preserv 79%
Martin
2008
172
Stage III+IV
Stage III (5 yy)
OS: 64%
DSS: 86%
Stage IV (5 yy)
OS: 41%
DSS: 57%
LC T3 75% (n=75)
(82% plus adjuvant RT vs 66%
without)
LC T4 57% (n=28)
Experience with TLM is still very limited and only few institutions have a consistent cohort
Can the intensity of adjuvant treatment be really reduced after TLM
or will it only increase side-effects???
After TLM for III-IV stage, patients
received adjuvant (C)RT
Local control rates are better than
those obtained with (C)RT alone
Not
recommended as
a first-line
treatment in every
institution
Vilaseca et al, Curr Opin Otolaryngol Head Neck Surg 2012
TRANSORAL LASER MICROSURGERY
Oncological results in advanced T-stages (T3-4)
mercoledì 29 giugno 16