144-145 / 2351
SCC Gene Expression
Mutated genes in H&N
Gene symbol
Function
Targets
TX
Mut rate
TP53
Tumor
p21,BAX,
PUMA
Adenovirus based
l
t
40-60%
suppressor
repa cemen
NOTCH1
Bivalent
Hes/Hey, p21 Secretase i
15%
HRAS
Oncogene
Raf/MEK/ERK
PI3K/AKT
Dsi: MEK/AKT i
Farnesyltransferase
Antisense
4-35%
PIK3CA
Oncogene
Akt,
PLCgamma1
PI3Ki
Dsi: Akt, mTOR
6-8%
CDKN2A
Tumor
suppressor
CDK 4/6
CDKi
9%
66