1708-1709 / 2351
Skin toxicity: Radiation dermatitis
Radiation
RT RT+CT Systemic treatment
dermatitis 3/4
RTOG 95 01
21% 14% Cisplatin 100 mg/m2 day 1 22 43
-
,
, ,
RTOG 91-11
9% 7% Cisplatin 100 mg/m2, day 1, 22,43
Bonner
18% 23% Cetuximab
Around 15-20% related to:
the total dose of RT and the RT field,
the dose per fraction,
CT or cetuximab
Cooper et al. NEJM 2004
Forastiere et al. NEJM 2003
Bonner et al. NEJM 2006