1720-1721 / 2351
Systemic skin toxicity with anti-EGFR
B
C
D
(A) Papular lesions on the chest; (B) papulopustular eruption on the back;
(C) l
f f lli l
t l
(D)
fl
t
t l
th
60-80%
Macular, papular, p stul r rash, = acne-like rash (or folliculitis)
c ose-up o o cu ar pus u es; con uen pus u es on e nose
Sometimes: severe pruritus
Segaert S, Van Cutsem E. Ann Oncol 2005