2054-2055 / 2351
Randomized trials with taxanes
Gibson et al JCO 2005
•
Cisplatin (100 mg/m2, day 1)/5-FU (1000 mg/m2/d, day 1-4), every 3 weeks
•
Cisplatin (75 mg/m2, day 1)/paclitaxel (175 mg/m2, day 1), every 3 weeks
Regimens
N ORR
(%)
Median survival
(months)
Cisplatin/5-FU
versus
Cisplatin/paclitaxel
218
27%
26%
8.7
8.1