432-433 / 2351
Validating the hypoxia classifier
Independent clinical dataset
414 patients enrolled in
the DAHANCA 5 trial
219 randomly assigned to
radiotherapy and nimorazole
195 randomly assigned to
radiotherapy and placebo
52 excluded from
classification
(2 failed in PCR,
50 did not
39 excluded from
classification
(1 failed in PCR,
38 did not
have tumour tissue for
PCR)
have tumour tissue for
PCR)
Nimorazole group:
Placebo group:
323 t
l
f
l
ifi ti
167 for classification
156 for classification
umour samp es or c ass ca on
Classification
”More” hypoxic
”Less” hypoxic
(114)
(209)
s” hypoxic (209)
Toustrup K et al, Radiother Oncol; 102; 122-129, 2012