436-437 / 2351
EORTC/DAHANCA 29 randomized phase III
LARYNX PHARYNX*
* Except NPC
Role of Nimorazole in chemo‐radiation of HPV neg HNSCC
,
HPVneg (p16); Stage 3‐4 (T2‐4,N0‐3)
Accl RT(6 fx/wk) +cisPl
Stratify:
OMIZE
Stage
Site
640 patients – (>200 with positive hypoxic gene profile).
Pi t l t i l t t bli h th t i di ti
f Ni
l i
RAND
Inst.
Hypox.
Gene profile
(retro specti e)
vo a r a o es a s e rue n ca on o morazo e n
Chemoradiotherapy of advanced HNSCC and the value of the hypoxic
gene profile
+ Nimorazole
(1.2 g/m2)
Accl RT(6 fx/wk) +cisPl
‐
v