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Fractionation sensitivity
Early reacting normal tissues
•
Low fractionation
sensitivity
Late reacting normal tissues
•
High fractionation
sensitivity
•
Small increase in tolerance
with decreasing dose per
fraction
•
High alpha-beta (8-30 Gy)
•
Time factor (repopulation)
•
Large increase in
tolerance with decreasing
dose per fraction
•
Low alpha-beta (2-4 Gy)
•
No time factor