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Conclusions – hypoxia
•
A significant proportion of HN squamous cell
carcinomas contains hypoxic regions
•
Patients with hypoxic tumours have poorer
loco-regional control and survival
•
Hypoxic modification (sensitizers, HBO,
hypoxic cytotoxins) during RT results in
improved loco-regional control and survival
•
Predictive assays, hypoxic imaging and
dosepainting is emerging but still
investigational