612-613 / 2351
Placebo
Nimorazole
50%
36%
Events All
Placebo
Nimorazole
HR=0.71 (0.53 to 0.95)
96 156
83 167
P=0.02
Effect of hypoxic modification
0
25
50
75
100
Loco-regional control (%)
0 12 24 36 48 60
Time after treatment (months)
Unclassified patients (n=323)
Hypoxia-classification
15-gene hypoxia classifier
Placebo
Nimorazole
49%
18%
Events All
Placebo
Nimorazole
HR=0.46 (0.29 to 0.75)
34 43
33 71
P=0.001
More hypoxic tumours
0
25
50
75
100
Loco-regional control (%)
0 12 24 36 48 60
Time after treatment (months)
Placebo
Nimorazole
50%
44%
Events All
Placebo
Nimorazole
HR=0.85 (0.58 to 1.23)
62 113
50 96
P=0.39
Less hypoxic tumours
0
25
50
75
100
Loco-regional control (%)
0 12 24 36 48 60
Time after treatment (months)
(n=114)
(n=209)
-Toustrup K et al, Radiother Oncol; 102; 122-129, 2012