610-611 / 2351
414 patients enrolled in
the DAHANCA 5 trial
219 randomly assigned to
radiotherapy and nimorazole
195 randomly assigned to
radiotherapy and placebo
52 excluded from
classification
(2 failed in PCR,
50 did not
39 excluded from
classification
(1 failed in PCR,
38 did not
Validating the hypoxia classifier
Independent clinical dataset
have tumour tissue for
PCR)
have tumour tissue for
PCR)
”More” hypoxic
”Less” hypoxic
Nimorazole group:
167 for classification
Placebo group:
156 for classification
323 tumour samples for classification
Classification
(114)
(209)
s” hypoxic (209)
Toustrup K et al, Radiother Oncol; 102; 122-129, 2012