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Hypoxia-classification
15-gene hypoxia classifier
•
Based on hypoxia induced genes (in vitro/in vivo
validated)
•
Classification based on gene expression similarity
to either ”more” or ”less” hypoxic tumours as
estimated with pO
2
-electrode in an independent
trainingset of 58 H&N cancer patients
Head and neck tumours (n=58)
0
5
10
15
20
25
30
35
40
45
50
55
Hypoxic fraction (%)
0
20
40
60
80
100
pO 2 -measurements < 2,5 mmHg
More
Hypoxic
Less
Hypoxic
Toustrup K et al,
Cancer Res; 71(17);
5923-31, 2011