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Larynx preservation with
induction CT : 3 randomized trials
MACH-NC
Meta-Analysis of
Chemotherapy
in Head & Neck Cancer
Trial
Main Site
(# of pts)
Subsite
VALCSG
Larynx
Glottic/subglottic
37 %
63 %
(n=332)
L
Supraglottic
Glottic/subglottic
41 %
GETTEC arynx
(n=68)
Supra glottic
2/3 sites
31 %
28 %
EORTC
Hypopharynx
( 202)
Hypopharynx
Lateral epilarynx
78 %
22 %
n=
IGR 10.00
Lancet 2000;355:949-55