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Larynx preservation with

induction CT : 3 randomized trials

MACH-NC

Meta-Analysis of

Chemotherapy

in Head & Neck Cancer

Trial

Main Site

(# of pts)

Subsite

VALCSG

Larynx

Glottic/subglottic

37 %

63 %

(n=332)

L

Supraglottic

Glottic/subglottic

41 %

GETTEC arynx

(n=68)

Supra glottic

2/3 sites

31 %

28 %

EORTC

Hypopharynx

( 202)

Hypopharynx

Lateral epilarynx

78 %

22 %

n=

IGR 10.00

Lancet 2000;355:949-55