VG H&N course intro Florence 2016.pptx

Study Design

N = 173

I d ti

PF x 1→RT

CR, PR

Response

n uc on

PF x 2

Surgery→RT

SD, PD

N = 172

Concurrent P x 3 + RT

N = 173

RT l

P i

d i

a one

r mary en po nt:

Larynx preservat on

Secondary endpoints: OS, DFS, laryngectomy-free survival

Forastiere AA, et al. N Engl J Med 2003;349:2091-8; Forastiere AA et al. ASCO 2006. Abstract 5517.

Primary organ preservation with surgical salvage accepted for all 3 study arms.

Neck dissection included N

disease.