700-701 / 2351
CRT: Late toxicity
•
Analysis of 230 patients receiving CRT in 3 studies (RTOG 91-11, 97-03, 99-14)
•
Factors associated with development of severe late toxicity
a
– Older age (p=0.001), advanced T-stage (p=0.0036), larynx/hypopharynx
primary (p=0.004), neck dissection after RT (p=0.018)
50
43%
40
s (%)
10%
12%
27%
13%
20
30
Patient
0
10
Any severe
late toxicity
Feeding tube
dependence
>2 yrs post-RT
Pharyngeal
dysfunction
Laryngeal
dysfunction
Death
a
Chronic grade 3 4 pharyngeal/laryngeal toxicity and/or requirement for feeding tube >2 years after registration and/or
-
potential treatment-related death within 3 years
Machtay M, et al. J Clin Oncol 2008;26: e-pub June 16