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Study Design
N = 220 patients (7 ineligible)
Total
Laryngectomy +
110 in TPF arm and 103 in the PF arm
PF
x 3
post-op RT for
nonresponders
R
Response
to
TPF x 3
RT alone for
responders
induction
treatment
Primary endpoint:
•
Larynx preservation
Secondary endpoints
•
Overall survival, DFS, toxicity
Calais G, et al.