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Anal Cancer : the importance of nodal
metastasis
•
Das et al ( 2007 ) : 167 patients treated with CRT
3 yr locoregional control 3 yr distant control
N0 85 % 94 %
N1 88 % 79 %
N2 84 % 75 %
N3 39 % 76 %
N stage an independent predictor of loco-regional failure, distant
metastasis and OS on multivariate analysis !
Ajani et al ( 2010 ) : RTOG 98-11 trial
Clinically positive nodes associated with worse 5 yr DFS and 5 yr OS ( p <
0.0001 )