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Human Papilloma Virus & Anal Carcinoma
•
Vuyst et al ( 2009 ) – meta-analysis of 29 international studies
between 1986 – 2008
Overall prevalence of HPV in AIN =
92.7 %
( 1280 cases )
Overall prevalence of HPV in anal carcinoma =
84.3 %
( 955 cases )
All types HPV 16 HPV18
Multiple
types
AIN 1
91.5 % 37.2 % 21.3 % 54.4 %
AIN 2 & 3 93.9 % 59.8 % 17.4 %
SCC
84.3 % 73.4 % 5.2 % 6.8 %
•
? HPV more common in basaloid variant SCC ( > 95 % )
•
? HPV associated lower T stage & N stage at diagnosis