377 / 1068
The Royal Marsden
The tumours that require preoperative
therapy because of poor prognosis:
•
TME plane CRM involvement
•
Depth of extramural spread >5mm risk factor for poor DFS
•
Presence of MRI detected venous invasion – risk factor for
local and distant recurrence and seen more frequently
than path EMVI
•
MRI detected mucinous tumours
•
MRI Nodal involvement in the absence of any of the above
does not confer any significant additional risk of either
local or distant relapse