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The Royal Marsden
Assessing response
Method
Prospectively validated against DFS
outcomes
MRI DWI
No – many retrospective quantitative cut-offs and
qualitative assessments – none prospectively
validated
DCE-MRI
No – many retrospective values proposed –
none validated
PET-CT
No – but retrospective SUV cut-offs proposed –
unverified prospectively
mrVolume assessment
Yes: >80% volume reduction
mrTRG
Yes : TRG1-5 validated prospectively and
against outcomes
mrT and mrN stage
validated prospectively and against outcomes