404 / 1068
The Royal Marsden
Enrolment
mrTRG1 -2 @4-6 weeks post CRT no viable disease
(low signal intensity fibrotic scar tissue only)
confirmed by MRI @ 8-12 weeks
mrTRG3 @ 4-6 weeks post CRT a good partial response
Continued incremental response on MRI @ 8-12 weeks
NOT
INITIALLY EXCLUDED EVEN IF:
DRE - Thickening of rectal wall or clinically palpable tumour
Endoscopically – mucosal abnormality
Pathology - Biopsy positive