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What is the mechanism of effect of preoperative CRT?
1. To prevent local recurrence by treating microscopic areas
not seen and so not routinely removed by surgeon
(discontinuous deposits etc ?
2. To prevent local recurrence by treating areas not routinely
removed by surgeon (external iliac nodes/obturator nodes
etc..) ?
3. To prevent local recurrence by countering spillage ie
rendering cells non-viable with RT?
4. To prevent local recurrence by countering spillage growing
ie tumour bed effect?
5. To prevent local recurrence by compensating for poor
surgical technique?
6. To prevent local recurrence by immune effects?