494 / 1068
Only 3 Randomised Trials
Publication
n Regimens in trial PCR in
Control
PCR in
Novel arm
RTOG 0012
J Clin Oncol 2006
T3/T4
106 PVI 5FU + 44.2Gy -
60Gy versus
PVI 5FU + Irinotecan
50.4Gy -54Gy
26%
26%
Jakobsen
IJROBP 2012
248 50.4Gy + UFT versus
50.4Gy + UFT+
Brachytherapy
18%
18%
Engineer
IJCRD 2013
90
45Gy + Cape
Versus
40Gy +20Gy RT
alone
7%
11%