552 / 1068
3. HDR-EBT – Boost after EBRT
- A dose-escalation phase III trial comparing 2 doses of radiation:
Jakobsen et al. Int J Radiat Oncol Biol Phys;84(4):949–54.
50,4 Gy in 28 fractions (n = 123)
50,4 Gy in 28 fractions + HDR-EBT boost 10 Gy in 2 fractions (n = 120)
- Both arms concomitant chemotherapy
-
Primary endpoint: pCR
- Secondary endpoints:
Tumor response
Rate of complete resection