804 / 1068
18
Unsolved questions
• Role of brachytherapy
• Management of inguinal region
• Type and scheme of CT
• Optimizing RT delivery
RTOG 0529
• Prospectively assess the utility of DP-IMRT in
reducing the acute morbidity of 5FU/MMC
chemoradiation
– Primary endpoint: reduction of grade 2+ GI and
GU AEs by at least 15%.
– Secondary endpoints:
• Potential reduction of all AEs with DP-IMRT
• The investigator’s ability to perform DP-IMRT
within the radiation planning guidelines
delineated
Kachnik, IJROBP 2013c