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C a r d i o v a s c u l a r D i s o r d e r s
Chapter 6
• Cardiovascular Disorders
69
Increased intra-arterial
pressure damages the
endothelium.
Angiotensin II induces
endothelial wall con-
traction, allowing
plasma to leak through
interendothelial spaces.
Plasma constituents
deposited in the vessel
wall cause medial necrosis.
Angiotensin
Fibrinogen
Medial necrosis
Platelet
BLOOD VESSEL DAMAGE IN HYPERTENSION
Treatment
Goal is to avoid target organ damage and complications.
•
Treatment of underlying cause if secondary HTN
•
Lifestyle modifications to reduce risk factors
•
Diuretics
•
Angiotensin-converting enzyme inhibitors
•
Alpha-receptor agonists
•
Beta-adrenergic blockers