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Equipoise
What about the principle of equipoise?
Clinical equipoise means that there is genuine uncertainty in the expert
medical community over whether a treatment will be beneficial. This applies
also for off-label treatments performed before or during their required
clinical trials.
van der Voort S, van de Water S, Perkó Z, Heijmen B, Lathouwers D, Hoogeman M.
Robustness Recipes for Minimax Robust Optimization in Intensity Modulated Proton
Therapy for Oropharyngeal Cancer Patients. IJROBP 2016 May 1;95(1):163-70.
Robustness
recipe vs.
margin recipe