Biophysical Society Thematic Meeting | Singapore

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Mechanobiology of Disease Poster Abstracts
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61-POS Board 61
Particle-based Modeling and Simulation of Cells in Flow
Kirill Lykov1, Yasaman Nematbakhch2, Chwee Teck Lim2, Igor V. Pivkin1.
1University of Lugano, Lugano, Switzerland, 2National University of Singapore, Singapore,
Singapore.
We developed a computational framework for simulations of red blood cells in fluid domains
using particle-based Dissipative Particle Dynamics (DPD) method. The use of DPD provided a
unified way to describe fluid, fluid-structure and structure-structure interactions. The framework
was employed in simulation of a wide range of blood rheology problems, such as analysis of the
flow in the lab-on-a-chip devices and studies of cell transport in the microvascular networks. We
recently extended the framework by developing a new model for cells with nucleolus, such as
white blood cells and circulating tumor cells. We will present the new cell model and its
validation using quantitative data from microfluidic experiments.