1216 / 1311
Accuracy for lymph node metastases
50 : 50
Possible remedies
Prostate
Benign
carcinoma
hyperplasia
Dynamic, contrast-enhanced MRI
•
Description of signal time curve
•
Pharmacokinetic 2-compartmental
model
High-resolution Contrast MRI
Lipids
Ci
Cr
Cho
δ
[ppm]
4.0 3.0 2.0 1.0 0.0
4.0 3.0 2.0 1.0 0.0
Cr
Cho
δ
[ppm]
Ci
Normal
Carcinoma
Spectroscopy
•
Metabolites:
–
Choline (Cho) = Proliferation marker
–
Citrate (Ci), produced by prostatic cell
= specific marker for vital glandular tissue
–
BPH: Citrate moderately decreased
–
Carcinoma: Citrate decreased, choline increased
1
1
2
2
Cho
Cho
Cr
Cr
Ci
Ci
Lip
Lip
Carcinoma
Benign hyperplasia
MRS in prostate cancer
•
Grading/Characterization:
MR Spectroscopy