311 / 1311
21.05.14 |
StefanDelorme
Division ofRadiology
Outline
•
Types of breast cancer
•
Imaging methods and features
•
Mammography
•
Ultrasound
•
CT
•
MRI
•
T stages
•
Nodal drainage and N Stages
•
Treated breast cancer
21.05.14 |
StefanDelorme
Division ofRadiology
Response: Tumor cells
•
Apoptosis
–
Early (hours to days)
–
Single-cell pattern
–
No inflammatory reaction
–
Phagocytosis by neighbor cells
•
Necrosis
–
Delayed (next mitosis, possibly after several cycles)
–
Grouped cell pattern
–
Inflammation
–
Phagocytosis by macrophages
21.05.14 |
StefanDelorme
Division ofRadiology
Response: Tumor stroma
•
Regression of cellular components
–
Lack of stimulation by tumor cells
–
Very delayed
•
Often persistence of fibrous components
•
Regression of vasculature
–
Lack of angiogenic stimulation
–
Direct treatment effects on vessels
»
Radiation
»
Anti-angiogenic treatment etc.
»
Chemotherapy
21.05.14 |
StefanDelorme
Division ofRadiology
Breast cancer: Possible response patterns
21.05.14 |
StefanDelorme
Division ofRadiology
Microcalcifications
Before chemotherapy
After chemotherapy
21.05.14 |
StefanDelorme
Division ofRadiology
US: Partial response