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3

32 „events“ in 151 patients

Actuarial rate 3y: 24%

Dose Effect relationship for late rectum side effects

based on points (ICRU reference points)

Vienna 93-97

BED ~120-130 Gy

3

„cut-off

level“ in recent experience

Iso-effective dose in 2Gy/fr

~ 70-80 Gy

ab3

,2Gyfr

no clear dose effect relations

bladder, sigmoid, vagina

More evidence: overview in Gerstner et al. R&O 2004

J. Fowler, Knocke, Pötter 1998 unpublished