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Linking DVH-parameters to clinical outcome

HR CTV/Tumour

Analysis (n=141, FIGO: IB-IVA, median follow-up=51 months)

D90 for the HR-CTV and probability of local control

1

Probability of local control

0 10

20 30

50 40

90

100

70 60

80

110 120 130 140

0

0.1

0.2

0.3

0.5

0.4

0.9

0.7

0.6

0.8

D90 (HR CTV)

Entire population (n=141)

Tumours > 5cm (n=76)

Dimopoulos et al. IJROBP 2008

D90

HR CTV

90 Gy EQD2

>86% probability for local contr

D90

HR CTV

70 Gy EQD2

65% probability for local control

Dimopoulos et al., R&O 2010

HR CTV D90 ≥ 86 Gy

EQD2(α/β10)

≥ 90% local control