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Linking DVH-parameters to clinical outcome
HR CTV/Tumour
Analysis (n=141, FIGO: IB-IVA, median follow-up=51 months)
D90 for the HR-CTV and probability of local control
1
Probability of local control
0 10
20 30
50 40
90
100
70 60
80
110 120 130 140
0
0.1
0.2
0.3
0.5
0.4
0.9
0.7
0.6
0.8
D90 (HR CTV)
Entire population (n=141)
Tumours > 5cm (n=76)
Dimopoulos et al. IJROBP 2008
D90
HR CTV
90 Gy EQD2
>86% probability for local contr
D90
HR CTV
70 Gy EQD2
65% probability for local control
Dimopoulos et al., R&O 2010
HR CTV D90 ≥ 86 Gy
EQD2(α/β10)
≥ 90% local control