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24

Vaginal stenosis

and

ICRU recto-vaginal point (630 pts)

K Kirchheiner et al, EMBRACE data

MUW/AUH, RadiothOncol 2016

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

3M 6M 9M 12M 18M 24M 30M 36M

G0

G1

G2

G3

Prevalence vaginal stenosis

Kirchheiner K et al.Manifestation pattern of early-late

vaginal morbidity. IJROBP 2014 May 1;89(1):88-95

Cox-regression, 2 year actuarial risk

of ≥G2 stenosis

- Significant impact of EBRT dose

(45Gy versus 50Gy)

- Significant impact of BT ICRU

recto-vaginal dose