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What do we know about dose to pathological nodes?
In literature still some uncertainty !
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Escalation typically recommended up to 55-60Gy
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SIB IMRT – 55Gy/25# with option of sequential boost -10Gy/5#
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FDG avid nodal disease -62Gy/31# SIB
Grigsby PW, et al Int J Radiat Oncol Biol Phys 2
001, 49(3):733–738.
Beadle BM, et al Int J Radiat Oncol Biol Phys 2010, 76(5):1396–1403.
Courtesy Ina Jürgenliemk-Schulz
Pelvic nodal control in N1 EMBRACE patients: 7%