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Page Background

Patient reported

subjective symptoms

Patient reported

objective symptoms

Physician assessed

objective symptoms

Analytic outcomes

(lab / imaging)

Physician assessed morbidity

Common Toxicity Criteria of AE

Patient reported impact of

symptoms on ADL

objective

subjective

clinical decision / medical intervention

Patient reported complex

multidimensional concepts

Combined information is

translated by physician

into medical terms and grades

Symptoms e.g., rectal discomfort,

passing blood or mucus;

medical intervention indicated;

limiting instrumental activities of

daily life

CTCAE v4. Proctitis G2

Depends on the interpretation of

the physician

Translation problems may be

assumed!