1576 / 1726
Atkinson et al. Qual Life Res 2012
N=393 patients, mixed cancer type
CTCAE assessed by 2 independent physicians within ~1h
Results in symptomatic patients
15-43% agreement
51-70% 1 grade differences
1-18% 2 grades differences
CTCAE agreement between
2 physicians is moderate at best!
The lower the CTCAE grading, the more variation between physicians is observed.
Disagreement mainly between G0/G1/G2.
Chinnachamy et al. Jpn J Clin Oncol 2013
Inter-rater reliability of CTCAE
morbidity assessment