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Bone Marrow
Around 50% of adult BM located in
lower L spine and pelvic bones
White blood cell count
Hemoglobin
Platelet count
Pelvic RT
Mell LK. IJROBP 2006
Sacks EL. Cancer 1978
Rubin P. Cancer 1973
Brixey CJ. IJROBP 2002
Lujan AE. IJROBP 2003
Fiorino C. Radiother Oncol 2009
Ahmed RS IJROBP 2004
Roeske JC Radiother Oncol 2005
Concomitant ChT increases BM toxicity
•
Red BM is active compartment
•
High sensitivity for radiation
•
Repopulation capability