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General Remarks (uncertainties)
•
Missing Clear Links between DVH parameters and Toxicity
•
Bowel = Small + Large Bowel in most studies
•
Highly mobile organ:
Only
20% occupies same position during the course of treatment
Blurring the evidence on DVH - Toxicity relations
Kavanagh BD, et al. IJROBP 2010
Muren LP. Radiother Oncol 2003
Kvinnsland Y. Radiother Oncol 2005
Hysing LB. Radiother Oncol 2006
Sanguinetti G. Radiother Oncol 2008
Fokdal L. Radiother Oncol 2005
Bowel