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5-year actuarial grade 1-4:

Overall EBRT 26% versus NAT 4%

Grade 1: EBRT 17% versus NAT 4%

Majority gastrointestinal tract

Grade 3-4 after EBRT 3%

4-field box technique less late complications

30% treated with parallel opposing fields

GOG#99 extended surgery + EBRT 13% grade 3-4

Creutzberg et al, IJROBP2001;

Keys et al 2004

PORTEC-1: morbidity